Semax (1 Vial)

Description

Semax — research-grade synthetic heptapeptide analog of ACTH(4-10), studied for nootropic, neuroprotective, and neurotrophic properties. Purity of 99%+ verified by HPLC and mass spectrometry, with batch-specific COA included. US-manufactured and shipped from domestic facilities.

What Is Semax?

Semax is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences. As an analog of the adrenocorticotropic hormone fragment ACTH(4-10), the molecule retains the neurotropic activity of the parent hormone without stimulating cortisol release from the adrenal cortex. This separation of actions is why the compound has drawn sustained interest in cognitive and neuroprotection research. For a broader discussion of short-chain brain peptides, see our cognitive enhancement guide.

Approved in Russia since 1994 for neurological indications such as transient ischemic attack, stroke recovery, and cognitive disorders, the compound has become one of the most extensively studied short-chain regulatory peptides for brain research worldwide. Laboratories across Europe, Asia, and North America have incorporated the molecule into models of learning, neuroplasticity, ischemic injury, and age-related cognitive decline.

The heptapeptide sequence Met-Glu-His-Phe-Pro-Gly-Pro resists enzymatic degradation better than the native ACTH(4-10) fragment, extending its biological half-life. This structural stabilization is one reason researchers prefer the analog for in vivo studies where consistent exposure is required over a sampling window of several hours.

Key Research Applications

• Neurotrophic factor regulation: Investigated for upregulation of BDNF and NGF expression in hippocampal and cortical tissue, with measurable changes observed within hours of administration in rodent models.
• Cognitive and memory research: Used in models of attention, executive function, working memory, and long-term memory consolidation, often paired with spatial learning tasks such as the Morris water maze.
• Neuroprotection studies: Studied for protective effects against ischemic neuronal damage, oxidative stress, and excitotoxic injury, including reduction of infarct volume in preclinical stroke models.
• Mood and motivation pathways: Modulates dopaminergic and serotonergic activity in preclinical models, with downstream effects on exploratory behavior and stress response.
• Gene expression profiling: Transcriptomic studies report altered expression of over 20 genes involved in immune response, vascular function, and neuroprotection following administration.

Product Specifications