Description
Buy Epitalon — research-grade synthetic tetrapeptide (Ala-Glu-Asp-Gly), ≥99% purity verified by independent HPLC and mass spectrometry, US-manufactured with a batch-specific Certificate of Analysis included in every order.
This short-chain tetrapeptide holds one of the most extensive peer-reviewed research profiles of any anti-aging compound, with studies spanning more than 35 years across in vitro, animal, and human observational models.
What Is Epitalon?
Epitalon (also written Epithalon or Epithalone, CAS 307297-39-8) is a synthetic tetrapeptide developed by Professor Vladimir Khavinson at the Saint Petersburg Institute of Bioregulation and Gerontology. The compound was designed based on Epithalamin, a natural peptide fraction extracted from bovine pineal gland tissue.
Researchers synthesized the four-amino acid sequence Ala-Glu-Asp-Gly to create a stable, reproducible research compound that could be studied without relying on biological extracts. For a broader overview of the peptide research landscape, see the complete guide to peptides or the peptide glossary.
Key Research Applications
- Telomere elongation: Epitalon activates telomerase reverse transcriptase (hTERT), enabling DNA telomere elongation in human somatic cells and counteracting the Hayflick limit of replicative senescence.
- Pineal gland regulation: The tetrapeptide modulates melatonin synthesis in the pineal gland, potentially restoring age-related declines in melatonin production that contribute to disrupted circadian rhythms and reduced antioxidant defense.
- Antioxidant enzyme support: Research demonstrates the compound increases superoxide dismutase (SOD), catalase, and glutathione peroxidase activity, reducing oxidative DNA damage and lipid peroxidation markers in aged animal models.
- Neuroendocrine normalization: Studies in aged animal models document normalized anterior pituitary function and restored luteinizing hormone and follicle-stimulating hormone pulsatility following administration.
- Cellular senescence research: As a telomerase activator, this compound is a primary research tool in studies of cellular senescence, replicative lifespan, and the biology of the Hayflick limit.
Product Specifications
| Peptide | Epitalon (Epithalon / Epithalone) |
| CAS Number | 307297-39-8 |
| Sequence | Ala-Glu-Asp-Gly |
| Molecular Weight | 390.35 g/mol |
| Purity | ≥99% (third-party HPLC and mass spectrometry) |
| Form | Lyophilized (freeze-dried) powder |
| Storage | Lyophilized: −20°C. Reconstituted: 2–8°C, use within 4 weeks. |
| Testing | Batch-specific COA included |
| Origin | US manufactured |
| Intended Use | Laboratory and research use only. Not for human consumption. |
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