Description
Buy MOTS-C — MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) is a 16-amino acid mitochondrial-derived peptide (MDP) with CAS 1627580-64-6. Available at PSPeptides with ≥99% purity verified by HPLC and mass spectrometry. US-manufactured, third-party tested, and supplied as lyophilized powder with a batch-specific Certificate of Analysis.
What Is MOTS-C?
MOTS-C is a groundbreaking mitochondrial-derived peptide encoded within the 12S rRNA gene of mitochondrial DNA. Discovered by Dr. Changhan David Lee at the University of Southern California in 2015, it represents a new class of signaling molecules — produced by the mitochondrial genome to communicate with the nuclear genome. Researchers who buy MOTS-C gain access to one of the most studied exercise mimetic peptides in metabolic biology.
MOTS-C activates AMPK (5′ AMP-activated protein kinase), the master metabolic regulator, and targets the folate-methionine cycle in skeletal muscle. This combination of mechanisms distinguishes buy MOTS-C research from other mitochondrial peptides currently under investigation.
Key Research Applications
- AMPK Pathway Activation: Buy MOTS-C to study the master metabolic switch that governs glucose uptake, fatty acid oxidation, and mitochondrial biogenesis.
- Exercise Mimetic Research: MOTS-C replicates key metabolic adaptations of physical exercise at the molecular level, making it a valuable tool for metabolic adaptation studies.
- Insulin Sensitivity Models: Published data shows MOTS-C improves insulin sensitivity and glucose homeostasis in diet-induced insulin resistance models.
- Longevity and Aging Research: Circulating MOTS-C levels decline with age; researchers buy MOTS-C to study age-related metabolic decline and potential interventions.
- Mitochondrial-Nuclear Signaling: MOTS-C crosses from mitochondria to the nucleus during metabolic stress, offering a unique window into inter-organelle communication.
Product Specifications
| Peptide | MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-C) |
| CAS Number | 1627580-64-6 |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| Molecular Weight | 2174.64 g/mol |
| Purity | ≥99% (HPLC & mass spectrometry verified) |
| Form | Lyophilized (freeze-dried) powder |
| Storage | Lyophilized: −20°C. Reconstituted: 2–8°C, use within 4 weeks. |
| Testing | Third-party tested; batch-specific COA included |
| Origin | US-manufactured |
| Intended Use | For laboratory research use only. Not for human consumption. |
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