Description
Buy Melanotan II — research-grade synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). Third-party HPLC and mass spectrometry verified at 99%+ purity. Lyophilized powder, US manufactured, supplied with batch-specific Certificate of Analysis for melanocortin receptor and melanogenesis research.
What Is Melanotan II?
Melanotan II (MT-II, CAS 121062-08-6) is a non-selective melanocortin receptor agonist developed at the University of Arizona in the 1990s. It binds to MC1R, MC3R, MC4R, and MC5R, giving it a broader receptor profile than its more selective counterpart Melanotan I (afamelanotide).
The peptide was originally investigated as a photoprotective agent because activation of MC1R stimulates melanogenesis, the biological process that produces melanin pigment in skin. Researchers who buy Melanotan II typically study melanocortin signaling, pigmentation biology, and energy homeostasis in laboratory models.
The cyclic lactam structure gives Melanotan II markedly better proteolytic stability than linear α-MSH analogs, which makes it practical for multi-hour in vitro incubations and standardized bench workflows. Laboratories that buy Melanotan II typically store it lyophilized and reconstitute small working aliquots as needed to preserve potency.
Key Research Applications
- Melanogenesis research: MC1R activation drives melanin synthesis, making Melanotan II a standard tool in pigmentation assays.
- Photoprotection models: Induced melanin absorbs and scatters UV radiation independently of sun exposure, useful in skin-damage prevention studies.
- Energy homeostasis: MC3R and MC4R activity modulates hypothalamic appetite circuits studied in feeding-behavior research.
- Comparative pharmacology: Side-by-side work against selective agonists clarifies receptor-subtype contributions.
- Melanocortin signaling mapping: Broad subtype activity supports whole-system models when paired with selective antagonists.
- Dermatological model systems: Used in cultured melanocyte and skin-equivalent assays exploring pigment biology.
Product Specifications
| Amount | 10 mg per vial (1 vial) |
| Purity | 99%+ (third-party HPLC and mass spectrometry) |
| Form | Lyophilized powder |
| CAS Number | 121062-08-6 |
| Molecular Formula | C50H69N15O9 |
| Storage | Store lyophilized at -20°C; reconstituted at 2–8°C |
| Testing | Batch-specific COA included |
| Origin | US manufactured |
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